RESEARCH ACTIVITIES

The research areas include

. Development of a prognostic signature for head and neck squamous cell carcinoma

. Exploring pathogenesis of salivary gland tumors.

. Oral Systemic connection.

. Development of treatments for Oral Lichen planus and Oral submucous fibrosis.

. Exploring genetic basis of developmental anomalies in indigenous population.

. Dental Public Health.

. Dental Education.

RESEARCH PROJECTS COMPLETED

. Correlation of mast cell and microvascular density in oro-facial neoplasms.

. Morphological study of oral mucosal changes in habitual paan chewers.

. Morphological study of maspin expression in oral squamous cell carcinoma.

. Tumour associated macrophages and microvascular density in oro-facial squamous cell carcinoma and basal cell carcinoma.

. Morphological changes in oral mucosa of rabbits induced by light emitting diode used as dental curing light.

. Oral cytopathological changes in habitual wet snuff (Naswar) dippers.

. Morphological changes induced by inorganic arsenic in jaw bones, tongue and buccal mucosa

of Wistar rats.

. Expression of prostanoids EP3 receptors in oral squamous cell carcinoma and adjacent normal

Tissue.

. Pathological changes in soft tissue associated with impacted third molars.

. Expression of matrix metalloproteinases in basal cell carcinoma and squamous cell carcinoma of head and neck.

. Ki-67 as a proliferative index in odontogenic jaw cysts.

. Cytological profile of oral mucosa and peri tumoral area in patients receiving concomitant

Chemoradiotherapy.

. Oral mucosal changes in patients of HIV /AIDS with or without Antiretroviral Therapy (ART).

. Gingival changes in patients having pulmonary tuberculosis.

. Determination of Cytotoxic T Cells and NK Cells in Papillary Carcinoma and Follicular Adenoma of Thyroid.

. Oral cytopathological changes in type 2 Diabetic patients.

. Effects of coconut water, coconut milk & coconut milk mixed with honey on healing of oral ulcers in rabbits.

. Expression of MSX2 in ankylosing temporomandibular joint.

. Oral cytopathological morphology in patients with chronic kidney disease.

. Oral cytopathological changes in systemic lupus erythematosus patients.

. Immunohistochemical expression of VEGF-C in papillary and follicular carcinoma of Thyroid.

. Expression of galectin-3 in pleomorphic adenoma, mucoepidermoid carcinoma & adenoid cystic carcinoma of salivary glands.

. CD10 and Osteopontin expression in odontogenic cysts and ameloblastoma.

. Immunohistochemical expression of EMMPRIN (CD147) in oral squamous cell carcinoma.

. Detection of metastatic head and neck squamous cell carcinomas using expression of tissue specific mir-205.

. Immunohistochemical expression of MUC-A in Head and neck squamous cell carcinoma.

. Immunohistochemical expression of PDGFR? in different grades of hand and neck squamous

cell carcinoma.

. Immunohistochemical expression of Hypoxia Inducible Factor 1-alpha (HIF 1-?) in patients of head and neck squamous cell carcinoma.

. Reversal of fibrosis by sulfasalazine in bleomycin induced oral submucous fibrosis (OSMF) of Wistar rats.

. Relationship between serum levels of interleukin-22 and oral manifestations in patients of systemic lupus erythematosus.

. Immunohistochemical expression of programmed death ligand 1 (PD-L1) in head and neck squamous cell carcinoma.

. Expression of programmed cell death 1 ligand 2 in adenoid cystic carcinoma and mucoepidermoid carcinoma of salivary glands.

. Association of long non-coding RNA HOTAIR and H1F1a gene in oral squamous cell carcinoma.

RESEARCH PROJECTS (ONRGOING)

. CDK4 mutations in exon 2 (g5051G>C and g5095G>C) in head and neck squamous cell Carcinoma.

. MiRNA differential expression in patients with head and neck squamous cell carcinoma before and after surgical therapy.

. Expression levels of long on coding RNAs pre and post CCRT and their association with clinical response in patients with head and neck squamous cell carcinoma.

. Single nucleotide polymorphisms in genes of wnt signaling pathway in association with facial morphology and protein expression in patients with non-syndromic cleft lip and palate.

. TFPI2 Methylation and protein expression in oral squamous cell carcinoma.

. GATA 4 Methylation and protein expression in oral squamous cell carcinoma.

. Immunohistochemical expression of PD-L1 on cancer associated fibroblasts in oral squamous cell carcinoma.

RESEARCH COLLABORATION

Academic and research collaboration is a very important in order to accelerate the progress and quality of the work. Therefore, Department of Oral Pathology collaborates with other institutes and hospitals for training of students and research such as.

. King Edward Medical University, Lahore

. Sheikh Zyed Hospital Lahore

. Services Institute of Medical Sciences (SIMS) Lahore

. Institute of Nuclear Medicine & Oncology Lahore (INMOL)

. Cleft Lip and Palate Hospital, Lahore.

.

Equipment List

The Department of Oral Pathology is fully equipped with latest scientific equipment.

Sr.No	Equipment Name
1	Autoclave Digital
2	Biological Safety Cabinet
3	Centrifuge machine
4	Freezer -80?
5	Digital Weighing Balance
6	Dry Block Thermostat
7	Dry heat Bath/Heat Blocks
8	Gel Electrophoresis System
9	Gel Documentation system
10	Automatic Ice Maker Flake
11	Microscope Penta head with Camera LC 30
12	Magnetic Hotplate Stirrer
13	Orbital Shaker
14	Micro Pipettes
15	Refrigerator
16	Digital Shaker Orbital
17	Thermal Cycler