Research Activities
Faculty Research Interests:
Dr Saqib Mahmood
- Medical Genetics
- Neurodegenerative Diseases
- Neuromuscular Diseases
- Dysmorphology
- Complex Genetic Disorders
Dr Irfan Ahmed
- Molecular Infectious Medicine
- Host Pathogen Interaction Studies
- Molecular Basis of Antimicrobial Drug Resistance
Dr Asim Pervaiz
- Molecular Medicine
- Cancer Genetics
- Functional Genomics of Cancer
Dr Sana Zahra
- Genetics of Hearing Impairment
- Genetics of Craniofacial Anomalies
Mr Syed Mohsin Raza
- Molecular Biology
- Molecular Virology
- Bioinformatics &Computational Biology
Ms Osheen Sajjad
- Molecular Oncology
- Hemoglobinopathies
- Congenital Bleeding Disorders
- Cytogenetics
Mr Aiman Shahzad
- Medical Genetics
- Neurodegenerative Disorders
- Functional Genomics
Grants Won:
1. Grant from Higher Education Commission worth Rs.1,720,740/- for "Inflammation in Stroke: Curriculum of Cytokines (TNF-Alpha & IL-10) and Homocystine in Clinical Stroke"
2. Grant from Higher Education Commission worth Rs.29,67,550/- for "Molecular Genetic Study in Pakistani Families with Schizophrenia
3. Grant from Pakistan Science Foundation worth Rs. 1,076,420/- for the project title "Molecular Genetic Studies in Pakistani Families with Autosomal Recessive Microcephaly"
4. Grant from Pakistan Science Foundation worth. Rs 592,000/- for the project title. "Molecular Genetics and Biochemical Studies in Familial Oculocutaneous Albinism (OCA)"
5. Grant from Punjab Higher Education Commission worth Rs.8,500,000/- for "Investigating the Genetic Landscape of Acute Lymphoblastic Leukemia"
6. Characterization of locally isolated strains of Acinetobacter baumannii for drug resistance and biofilm formation.
Start-up Research Grant Program (SRGP) by Higher Education Commission (HEC) of Pakistan Worth: 0.5million PKR (2016-2017)
7. Anticancer effects of Erufosine in breast and colorectal cancer cells
Start-up Research Grant Program (SRGP) by Higher Education Commission (HEC) of Pakistan Worth: 0.45million PKR (2016-2017)
8. Analysis of Acinetobacter baumannii for virulence features, drug resistance and alternative treatment options
National Research Program for Universities (NRPU) by Higher Education Commission (HEC) of Pakistan Worth: 8.23million PKR (2017-2020)
9. pre-clinical evaluation of a candidate drug for metastatic breast cancer
National Research Program for Universities (NRPU) by Higher Education Commission (HEC) of Pakistan Worth: 4.9million PKR (2018-2021)
10. Network on bridging gap in adaptive drug resistance and fitness properties of Gram-negative bacteria VR2020 Research Grant by Swedish Research Council, Sweden. Worth: 6 Million SEK (2020-21)
Research Thesis of Students
Sr. No. |
Student Names |
Title of Thesis |
1. |
Ayesha Rahim |
KLF1 Exon 2 variations and their association with HbF and HbA2 levels in beta thalassemia |
2. |
M. Ali |
Erufosine mediated effects on transcriptomic profile of tumor suppressors and oncogenes in breast cancer cells |
3. |
Ubaid Ullah |
Effects of erufosine on cell cycle related genes in liver cancer cell |
4. |
Nazakat Shafiq |
Riproximin mediated cytotoxic effects and expressional modifications in cell cycle related genes in liver cancer cells |
5. |
Kinza Kanwal |
Cytotoxic effects of alkyl-phospholipids (Erufosine and Perifosine) in combination with cell cycle check point inhibitors (ATM and ATR) in breast cancer cells |
6. |
Saba Saeed |
Effects of a ribosomal inactivating plant protein (riproximin) on transcriptomic profile of tumor suppressor and oncogenes in breast cancer cells |
7. |
Adeela Batool |
Riproximin mediated cytostatic effects and expressional modifications in cell cycle related genes in lung cancer cells |
8. |
Maryum Nasim |
Effects of erufosine on cell cycle and its related genes in lung cancer cells |
9. |
Kiran Riaz |
Effects of riproximin on expressional profiling of apoptosis related genes in breast cancer |
10. |
Asma Khan |
Riproximin mediated effects on transcriptomic profile of PI3K/Akt/mTOR pathway in breast cancer cells |
11. |
Iqra Shaukat |
Toxic effects of synthetic alkyl-phospholipids (Erfufosine) in combination with chemotherapeutic agents (5-FU and Oxaliplatin) against colorectal cancer cells |
12. |
Talha Saleem |
Effects of riproximin on expressional profiling of anticancer genes in breast cancer cells |
13. |
Sobia Javeed |
Effects of CCR5 and CXCR4 blockage on cell survival and expression levels of apoptosis related genes (FAS, FASL) in hepatocellular carcinoma cells |
14. |
M. Masood |
Effects of synthetic alkyl-phospholipids on proliferation and cell cycle relevant genes (CCNA1, CCNA2, CCND1) of hepatocellular carcinoma cells |
15. |
M. Shoaib |
Molecular basis of cell cycle arrest by erufosine in breast and colorectal cancer cells |
16. |
Syeda Shafia |
Riproximin mediated effects on cell cycle relevant genes in breast & colorectal cancer cells |
17. |
Syeda Faiza |
Circulating chemokine levels in colorectal cancer patients and healthy population |
18. |
Abdul Salam |
Levels of Serum Uric Acid in Young Adults |
19. |
Muhammad Arshad Nadeem |
Mutational Analysis of Thiopurine S-Methyltransferase (TPMT) gene in Acute Lymphoblastic Leukemia Patients |
20. |
Sana Tariq |
Gene Expression Analysis of Adiponectin Receptor -2 and Insulin Receptor in Chronic HCV Patients with Type 2 Diabetes Mellitus |
21. |
Khadija Tahir |
Molecular Detection of TEM and CTX-M Genes in Extended Spectrum-?-Lactamases (ESBL) Producing Gram-Negative Rods |
22. |
Sidra Javed |
Anti Mullerian Hormone as a marker of ovarian dysfunction and insulin resistance in PCOS patients. |
23. |
Sana Tamoori |
Prevalence of Antithyroid antibody in Patients of Hepatitis C Infection of Genotype 3a |
24. |
Saeeda Riaz |
Gene Expression Analysis of Tumor Necrosis Factor Alpha (TNF-alpha) and Insulin Receptor Substrates in Patients of Chronic Hepatitis C Virus with Type-II Diabetes Mellitus |
25. |
Faqeeha Javed |
Frequency of Staphylococcal Cassette Chromosome Mec Type IV and Type V in Clinical Isolates of MRSA |
26. |
Saba Munir |
Molecular Detection of Isoniazid, Rifampin,, Ethambutol resistance of Mycobacterium Tuberculosis and Mycobacterium Bovis in Multidrug resistance tuberculosis patients. (Saba Munir) |
27. |
Gulashan Ara |
A genetic Association Study Based on Analysis of SNP-560 C>T on T-Cell Receptor (TCR) Gene in Patients of IgA Nephropathy (IgAN) |
28. |
Fatima Shabbir |
1Expression Analysis of Tumor Necrosis Factor Alpha (TNF-alpha) and Nuclear Factor Kappa alpha (NFk-alpha) in Patients of Chronic Hepatitis C Virus of Genotypes 3a |
29. |
Sobia Rizwan |
Genetic polymorphism in FTO gene in polycystic ovary syndrome patients |
30. |
Ghulam Rasool |
Comparison of Different Staining Techniques in the Identification of Acid Fast Bacilli in Tuberculous Lymph Node Tissue |
31. |
Hajra Azhar |
Vaginal Carriage of K1 Escherichia Coli during Third Trimester of Pregnancy |
32. |
Raima Rehman |
To Assess Microbiological Quality of Ready to Eat Salads available at different Outlets in Lahore |
33. |
Faiza Yasmeen |
Effect of CYP2C9 Polymorphism in Warfarin Therapy Patients |
34. |
Aisha Majeed |
Soluble Serum Transferrin Receptor (sTfR) Level in Hemodialysis Patients |
35. |
Muhammad Jawad |
Hepcidin Levels in Multi Transfused beta Thalassemia Major Patients |
36. |
Sana Qayyum Khan |
Correlation of Parathyroid Hormone and Magnesium with Vitamin D Deficiency |
37. |
Hina Mohiuddin |
Association of Serum Ascites Albumin Gradient (SAAG) with Causes of Ascites in Hemodialysis Patients |
38. |
Muqaddas Riaz |
Determination of Anti Thyroid Antibodies in Systemic Lupus Erythematosus Patients |
39. |
Sehrish Kanwal |
Exploitation of Standard Modified Hodge Test for the Detection of Extended Spectrum Beta Lactamase Production |
40. |
Nabila |
Relationship Between the Susceptibility of Typhoidal Salmonellae to Ciprofloxcin, Ofloxacin and their Respective Susceptibility to Nalidixic Acid |
41. |
Saira Munir |
In vitro antimycobacterial activity of Pakistani beri honey using MGIT 960 |
42. |
Hafeez Ullah |
Circadian Clock Gene �Per2 Mutations in Chronic Lymphocytic Leukemia |
43. |
Warda Hussain |
Reference Ranges of Trace Elements (Fe, Zn & Cu) in Adult Population (20- 29 years) of Lahore |
44. |
Fauzia Sadiq |
Ghrelin Levels in Obese Children of Type 2 Diabetic Parents and its Correlation with Risk Parameters of Metabolic Syndrome |
45. |
Muhammad Atif |
Correlation of Glycated Hemoglobin with Zinc and Magnesium Levels in Patients with Type 2 Diabetes Mellitus |
46. |
Kanwal Azhar |
Knowledge and Attitude Regarding Quality Assurance and its Association with Practice among Medical Lab Technologists working in Laboratories of Lahore |
47. |
Mustafa Munawar |
Phenotype and Genotype Characterization of Eunuchs in Lahore |
48. |
Tauqeer Ali Butt |
Assessment of Thyroid Dysfunction in Children with Celiac Disease |
49. |
Fakhar-un-Nissa |
Association of Serum Levels of Zinc and Magnesium with Increased Levels of Glycated Hemoglobin in Patients with Type 2 Diabetes Mellitus |
50. |
Mr Sarwar Abbas |
Determination of CRP and IL-6 in HCV positive and HCV Negative Patients of Chronic Renal Failure on Dialysis |
51. |
Sara Karim |
Determination of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients |
52. |
Maria Arif |
Frequency of Anti Netrophil Cytoplasmic Antibody and Anti Glomerular Basement Membrane Antibody in Glomerlonephritis Patients |
53. |
Muhammad Waqas Anjum |
Comparison of Different Methods for GFR Calculation in Pre-Dialysis Patients |
54. |
Sundas Fatima |
Assessment of Zinc and Copper in Nephrotic Syndrome |
55. |
Sumaira Farooqi |
Assessment of Aluminium, Zinc and Copper in Dialysis Patients |
56. |
Samra Shaukat |
Comparison of Alpha Fetoprotein in Hepatitis C Positive Patients of Liver Cirrhosis with and without Hepatocellular Carcinoma |
57. |
Farzana Yasmeen |
Comparison of Cation Exchange HPLC with Boronate Affinity Chromatography for Determination of HbA1c(Ms. Farzana Yasmeen). |
58. |
Syeda Aneela |
Metallo Beta Lactamase Producing Pseudomonas Aeruginosa Potent Enemy |
59. |
Kanwal Rauf |
Susceptibility Pattern Of Clinical Isolates of Salmonella Typhi against Ethanolic Extract of Garlic |
60. |
Sidra Shan |
Bacteriological Status of Drinking Water from 100 Families of Lahore by Membrane Filtration Technique |
61. |
Samra Asghar |
In Vitro Antibacterial Activity of Crude Leaf Extract of Mango (Mangifera Indica ) on Salmonella Typhi |
62. |
M. Usman Qamar |
Prevelance, Biotyping and Susceptibility Pattern of Coagulase Negative Staphylococci Isolated from cases of Neonatal Septicaemia in a Tertiary Care Hospital |
63. |
Amber Ilyas |
Levels of Antiphopholipid Antibodies in Female with Recurrent Abortions |
64. |
Muhammad Mahtab Aslam |
Evaluation of Platelet Dysfunction in Relation to Hematocrit in Patients with Uremia |
65. |
Khursheed Javaid |
CD4 and CD8 Ratio in Pleural Effusion of T.B and non T.B patients. |
66. |
Shahid Hussain |
Level of Interferon Gamma in Blood of T.B and non T.B patients. |
67. |
Muhammad Absar |
Comparison of Conventional Most Probable Number (MPN) With Standard Membrane Filtration Technique for the Bacteriological Analysis of Drinking Water. |
68. |
Mr. Faisal Nadeem |
Evaluation of Antimycobacterial Activity of Allium Sativum (Garlic Oil) Against 50 Strains of MDR-TB. |
69. |
Muhammad Ikram Ullah |
Anti-Typhoid Activity of Gatifloxacin as Compared to Other Anti Typhoid Fluroquinolones Marketed in Pakistan. |
70. |
Mr. Muhammad Arshad |
Frequency of Extended Spectrum Beta Lactamase Enzymes in Clinical Isolates of Enterobacteriaceae |
71. |
Muhammad Yasir |
Frequency of Carbapenemases in Enterobacteriaceae Isolated from Diagnosed Cases of Nosocomial Blood Stream Infections. |
72. |
Muhammad Bilal |
Significance of Homocysteine in Patients of Dialysis |
73. |
Shabbir Hussain |
Biochemical Evaluation of Erectile Dysfunction in Patients on Dialysis. |
74. |
Nadia Rasheed |
Assessment of Thyroid Dysfunction in Down Syndrome Patients. |
75. |
Tanveer Ahmed |
Lead Exposure in Children Living around Automobile and Battery Repair Workshop. |
International Collaborations
1. Prof. Dr. med. Christian Hubner
Head Institute of Human Genetics Functional GenomicsHead Institute of Instituts fur Humangenetik University Klinikum Friedrich Schiller University Jena Germany [email protected]
2. Prof. Dr. med. Martin Wabitsch
Head of the Division of Padiatric Endocrinology and Diabetes Ulm University Medical Center Department of Pediatrics and Adolescent Medicine Eythstr. 24 89075 Ulm, Germany e-mail: [email protected]
3. Azeez Butali, DDS, Ph.D. FICD
Professor of Craniofacial Genetics Member, Smile Train Research and Innovations Advisory Committee Member, American Society for Human Genetics Nominating Committee 2182 ML The University of Iowa, College of Dentistry Iowa City, IA 52242 USA